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chava kimchi
US FDA
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A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity
C Kimchi-Sarfaty, JM Oh, IW Kim, ZE Sauna, AM Calcagno, SV Ambudkar, ...
Science 315 (5811), 525-528, 2007
30452007
P-glycoprotein: from genomics to mechanism
SV Ambudkar, C Kimchi-Sarfaty, ZE Sauna, MM Gottesman
Oncogene 22 (47), 7468-7485, 2003
13972003
Understanding the contribution of synonymous mutations to human disease
ZE Sauna, C Kimchi-Sarfaty
Nature Reviews Genetics 12 (10), 683-691, 2011
11192011
Recent advances in (therapeutic protein) drug development
HAD Lagassé, A Alexaki, VL Simhadri, NH Katagiri, W Jankowski, ...
F1000Research 6, 2017
5382017
Exposing synonymous mutations
RC Hunt, VL Simhadri, M Iandoli, ZE Sauna, C Kimchi-Sarfaty
Trends in Genetics 30 (7), 308-321, 2014
3612014
Silent (synonymous) SNPs: should we care about them?
R Hunt, ZE Sauna, SV Ambudkar, MM Gottesman, C Kimchi-Sarfaty
Single nucleotide polymorphisms: methods and protocols, 23-39, 2009
3562009
Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer
ZE Sauna, C Kimchi-Sarfaty, SV Ambudkar, MM Gottesman
Cancer research 67 (20), 9609-9612, 2007
3362007
Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima
CJ Tsai, ZE Sauna, C Kimchi-Sarfaty, SV Ambudkar, MM Gottesman, ...
Journal of molecular biology 383 (2), 281-291, 2008
3052008
A new and updated resource for codon usage tables
J Athey, A Alexaki, E Osipova, A Rostovtsev, LV Santana-Quintero, ...
BMC bioinformatics 18, 1-10, 2017
2512017
Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma
JJ Gartner, SCJ Parker, TD Prickett, K Dutton-Regester, ML Stitzel, JC Lin, ...
Proceedings of the National Academy of Sciences 110 (33), 13481-13486, 2013
1982013
Functional Characterization of Coding Polymorphisms in the HumanMDR1 Gene Using a Vaccinia Virus Expression System
C Kimchi-Sarfaty, JJ Gribar, MM Gottesman
Molecular Pharmacology 62 (1), 1-6, 2002
1882002
Ethnicity-Related Polymorphisms and Haplotypes in the Human ABCB1 Gene
C Kimchi-Sarfaty, AH Marple, S Shinar, AM Kimchi, D Scavo, MI Roma, ...
Pharmacogenomics 8 (1), 29-39, 2007
1332007
MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer
KL Fung, J Pan, S Ohnuma, PE Lund, JN Pixley, C Kimchi-Sarfaty, ...
Cancer research 74 (2), 598-608, 2014
1282014
Codon and codon-pair usage tables (CoCoPUTs): facilitating genetic variation analyses and recombinant gene design
A Alexaki, J Kames, DD Holcomb, J Athey, LV Santana-Quintero, ...
Journal of molecular biology 431 (13), 2434-2441, 2019
1252019
Coagulopathy and thrombosis as a result of severe COVID-19 infection: a microvascular focus
UK Katneni, A Alexaki, RC Hunt, T Schiller, M DiCuccio, PW Buehler, ...
Thrombosis and haemostasis 120 (12), 1668-1679, 2020
1102020
Building better drugs: developing and regulating engineered therapeutic proteins
C Kimchi-Sarfaty, T Schiller, N Hamasaki-Katagiri, MA Khan, C Yanover, ...
Trends in pharmacological sciences 34 (10), 534-548, 2013
1082013
Sensitive measurement of single-nucleotide polymorphism-induced changes of RNA conformation: application to disease studies
R Salari, C Kimchi-Sarfaty, MM Gottesman, TM Przytycka
Nucleic acids research 41 (1), 44-53, 2013
952013
Pseudovirions as vehicles for the delivery of siRNA
PE Lund, RC Hunt, MM Gottesman, C Kimchi-Sarfaty
Pharmaceutical research 27, 400-420, 2010
902010
Characterization of Coding Synonymous and Non-Synonymous Variants in ADAMTS13 Using Ex Vivo and In Silico Approaches
NC Edwards, ZA Hing, A Perry, A Blaisdell, DB Kopelman, R Fathke, ...
Plos one 7 (6), e38864, 2012
822012
Single synonymous mutation in factor IX alters protein properties and underlies haemophilia B
VL Simhadri, N Hamasaki-Katagiri, BC Lin, R Hunt, S Jha, SC Tseng, ...
Journal of medical genetics 54 (5), 338-345, 2017
782017
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