Birte Höcker
Birte Höcker
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ProtGPT2 is a deep unsupervised language model for protein design
N Ferruz, S Schmidt, B Höcker
Nature communications 13 (1), 4348, 2022
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
PS Huang, K Feldmeier, F Parmeggiani, DA Fernandez Velasco, ...
Nature chemical biology 12 (1), 29-34, 2016
Oxygen-Insensitive Nitroreductases: Analysis of the Roles ofnfsA and nfsB in Development of Resistance to 5-Nitrofuran Derivatives in Escherichia coli
J Whiteway, P Koziarz, J Veall, N Sandhu, P Kumar, B Hoecher, ...
Journal of bacteriology 180 (21), 5529-5539, 1998
Catalytic Versatility, Stability, and Evolution of the (βα)8-Barrel Enzyme Fold
R Sterner, B Höcker
Chemical Reviews 105 (11), 4038-4055, 2005
Dissection of a (βα) 8-barrel enzyme into two folded halves
B Höcker, S Beismann-Driemeyer, S Hettwer, A Lustig, R Sterner
nature structural biology 8 (1), 32-36, 2001
Mimicking enzyme evolution by generating new (βα) 8-barrels from (βα) 4-half-barrels
B Höcker, J Claren, R Sterner
Proceedings of the National Academy of Sciences 101 (47), 16448-16453, 2004
Controllable protein design with language models
N Ferruz, B Höcker
Nature Machine Intelligence 4 (6), 521-532, 2022
Stability, catalytic versatility and evolution of the (βα)8-barrel fold
B Höcker, C Jürgens, M Wilmanns, R Sterner
Current opinion in biotechnology 12 (4), 376-381, 2001
A biosensor for the direct visualization of auxin
O Herud-Sikimić, AC Stiel, M Kolb, S Shanmugaratnam, KW Berendzen, ...
Nature 592 (7856), 768-772, 2021
Computational design of ligand binding is not a solved problem
B Schreier, C Stumpp, S Wiesner, B Höcker
Proceedings of the National Academy of Sciences 106 (44), 18491-18496, 2009
A robust protein host for anchoring chelating ligands and organocatalysts
MT Reetz, M Rentzsch, A Pletsch, A Taglieber, F Hollmann, ...
ChemBioChem 9 (4), 552-564, 2008
Establishing wild-type levels of catalytic activity on natural and artificial (βα) 8-barrel protein scaffolds
J Claren, C Malisi, B Höcker, R Sterner
Proceedings of the National Academy of Sciences 106 (10), 3704-3709, 2009
Divergent Evolution of (??) 8-Barrel Enzymes
M Henn-Sax, B Höcker, M Wilmanns, R Sterner
Walter de Gruyter 382 (9), 1315-1320, 2001
A βα-barrel built by the combination of fragments from different folds
TAM Bharat, S Eisenbeis, K Zeth, B Höcker
Proceedings of the National Academy of Sciences 105 (29), 9942-9947, 2008
Evolutionary relationship of two ancient protein superfolds
JA Farías-Rico, S Schmidt, B Höcker
Nature chemical biology 10 (9), 710-715, 2014
A common evolutionary origin of two elementary enzyme folds
B Höcker, S Schmidt, R Sterner
FEBS letters 510 (3), 133-135, 2002
Automated scaffold selection for enzyme design
C Malisi, O Kohlbacher, B Höcker
Proteins: Structure, Function, and Bioinformatics 77 (1), 74-83, 2009
Structure‐based design of robust glucose biosensors using a Thermotoga maritima periplasmic glucose‐binding protein
Y Tian, MJ Cuneo, A Changela, B Höcker, LS Beese, HW Hellinga
Protein science 16 (10), 2240-2250, 2007
Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template
MM Meier, C Rajendran, C Malisi, NG Fox, C Xu, S Schlee, ...
Journal of the American Chemical Society 135 (31), 11670-11677, 2013
ProteinTools: a toolkit to analyze protein structures
N Ferruz, S Schmidt, B Höcker
Nucleic acids research 49 (W1), W559-W566, 2021
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Artículos 1–20