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Manuel Sebastian Escotet-Espinoza
Manuel Sebastian Escotet-Espinoza
Principal Scientist at Merck & Co.
Dirección de correo verificada de merck.com
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Process analysis and optimization of continuous pharmaceutical manufacturing using flowsheet models
Z Wang, MS Escotet-Espinoza, M Ierapetritou
Computers & Chemical Engineering 107, 77-91, 2017
1152017
Effect of tracer material properties on the residence time distribution (RTD) of continuous powder blending operations. Part I of II: Experimental evaluation
MS Escotet-Espinoza, S Moghtadernejad, S Oka, Y Wang, ...
Powder Technology 342, 744-763, 2019
842019
Using a material property library to find surrogate materials for pharmaceutical process development
MS Escotet-Espinoza, S Moghtadernejad, J Scicolone, Y Wang, G Pereira, ...
Powder technology 339, 659-676, 2018
812018
Characterization and pharmacokinetic analysis of crystalline versus amorphous rapamycin dry powder via pulmonary administration in rats
SR Carvalho, AB Watts, JI Peters, S Liu, S Hengsawas, ...
European Journal of Pharmaceutics and Biopharmaceutics 88 (1), 136-147, 2014
582014
Effect of material properties on the residence time distribution (RTD) characterization of powder blending unit operations. Part II of II: Application of models
MS Escotet-Espinoza, S Moghtadernejad, S Oka, Z Wang, Y Wang, ...
Powder Technology 344, 525-544, 2019
572019
Discrete Element Modeling (DEM) for mixing of cohesive solids in rotating cylinders
MS Escotet-Espinoza, CJ Foster, M Ierapetritou
Powder Technology 335, 124-136, 2018
492018
A training on: continuous manufacturing (direct compaction) of solid dose pharmaceutical products
S Moghtadernejad, MS Escotet-Espinoza, S Oka, R Singh, Z Liu, ...
Journal of Pharmaceutical Innovation 13, 155-187, 2018
442018
Modeling the effects of material properties on tablet compaction: A building block for controlling both batch and continuous pharmaceutical manufacturing processes
MS Escotet-Espinoza, S Vadodaria, R Singh, FJ Muzzio, MG Ierapetritou
International Journal of Pharmaceutics 543 (1-2), 274-287, 2018
372018
Surrogate-based optimization for pharmaceutical manufacturing processes
Z Wang, MS Escotet-Espinoza, R Singh, M Ierapetritou
Computer Aided Chemical Engineering 40, 2797-2802, 2017
302017
Phenomenological and residence time distribution models for unit operations in a continuous pharmaceutical manufacturing process
M Escotet Espinoza
Rutgers University-School of Graduate Studies, 2018
242018
Flowsheet models modernize pharmaceutical manufacturing design and risk assessment: in silico design facilitates process optimization and evaluation of process control strategies
MS Escotet-Espinoza, R Singh, M Sen, T O'Connor, S Lee, S Chatterjee, ...
Pharmaceutical Technology 39 (4), 34-41, 2015
242015
Design of an integrated continuous manufacturing system
SS Oka, MS Escotet-Espinoza, R Singh, JV Scicolone, DB Hausner, ...
Continuous Manufacturing of Pharmaceuticals, 405-446, 2017
212017
Performance evaluation of a high-precision low-dose powder feeder
S Fathollahi, S Sacher, MS Escotet-Espinoza, J DiNunzio, JG Khinast
AAPS PharmSciTech 21, 1-13, 2020
202020
Development and use of a residence time distribution (RTD) model control strategy for a continuous manufacturing drug product pharmaceutical process
S Hurley, A Tantuccio, MS Escotet-Espinoza, M Flamm, M Metzger
Pharmaceutics 14 (2), 355, 2022
172022
Process simulation and control for continuous pharmaceutical manufacturing of solid drug products
M Ierapetritou, MS Escotet-Espinoza, R Singh
Continuous Manufacturing of Pharmaceuticals, 33-105, 2017
172017
Improving feedability of highly adhesive active pharmaceutical ingredients by silication
MS Escotet-Espinoza, JV Scicolone, S Moghtadernejad, E Sanchez, ...
Journal of pharmaceutical innovation 16, 279-292, 2021
122021
Optimization methodologies for the production of pharmaceutical products
MS Escotet-Espinoza, A Rogers, MG Ierapetritou
Process simulation and data modeling in solid Oral drug development and …, 2016
92016
Development of a controlled continuous low-dose feeding process
S Fathollahi, J Kruisz, S Sacher, J Rehrl, MS Escotet-Espinoza, ...
AAPS PharmSciTech 22, 1-14, 2021
72021
Mixing cell: a device to mimic extent of lubrication and shear in continuous tubular blenders
S Moghtadernejad, MS Escotet-Espinoza, Z Liu, E Schäfer, F Muzzio
AAPS PharmSciTech 20, 1-12, 2019
42019
Characterization of material properties
SM Razavi, S Oka, MS Escotet-Espinoza, Y Wang, T Li, M Futran, ...
How to Design and Implement Powder-To-Tablet Continuous Manufacturing …, 2022
22022
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