S P Lees-Miller, PhD, FRSC
S P Lees-Miller, PhD, FRSC
Department of Biochemistry & Molecular Biology, University of Calgary
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Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
BL Mahaney, K Meek, SP Lees-Miller
Biochemical Journal 417 (3), 639-650, 2009
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
KO Hartley, D Gell, GCM Smith, H Zhang, N Divecha, MA Connelly, ...
Cell 82 (5), 849-856, 1995
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase
SP Jackson, JJ MacDonald, S Lees-Miller, R Tjian
Cell 63 (1), 155-165, 1990
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
SP Lees-Miller, K Sakaguchi, SJ Ullrich, E Appella, CW Anderson
Molecular and cellular biology, 1992
DNA damage-induced activation of ATM and ATM-dependent signaling pathways
EU Kurz, SP Lees-Miller
DNA repair 3 (8-9), 889-900, 2004
ATM associates with and phosphorylates p53: mapping the region of interaction
KE Keating, S Kozlov, S Scott, M Gatei, K Hobson, Y Taya, B Gabrielli, ...
Nature genetics 20 (4), 398-400, 1998
Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line
SP Lees-Miller, R Godbout, DW Chan, M Weinfeld, RS Day III, GM Barron, ...
Science 267 (5201), 1183-1185, 1995
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen
SP Lees-Miller, YR Chen, CW Anderson
Molecular and cellular biology, 1990
Repair of DNA double strand breaks by non-homologous end joining
SP Lees-Miller, K Meek
Biochimie 85 (11), 1161-1173, 2003
DNA‐dependent protein kinase catalytic subunit: a target for an ICE‐like protease in apoptosis.
Q Song, SP Lees‐Miller, S Kumar, Z Zhang, DW Chan, GC Smith, ...
The EMBO journal 15 (13), 3238-3246, 1996
DNA‐PK autophosphorylation facilitates Artemis endonuclease activity
AA Goodarzi, Y Yu, E Riballo, P Douglas, SA Walker, R Ye, C Härer, ...
The EMBO journal 25 (16), 3880-3889, 2006
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
RA Woo, KG McLure, SP Lees-Miller, DE Rancourt, PWK Lee
Nature 394 (6694), 700-704, 1998
ATM Mediates Phosphorylation at Multiple p53 Sites, Including Ser46, in Response to Ionizing Radiation∗
S Saito, AA Goodarzi, Y Higashimoto, Y Noda, SP Lees-Miller, E Appella, ...
Journal of Biological Chemistry 277 (15), 12491-12494, 2002
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair
Q Ding, YVR Reddy, W Wang, T Woods, P Douglas, DA Ramsden, ...
Molecular and cellular biology 23 (16), 5836-5848, 2003
Structure of the RPA trimerization core and its role in the multistep DNA‐binding mechanism of RPA
E Bochkareva, S Korolev, SP Lees‐Miller, A Bochkarev
The EMBO journal, 2002
DNA-PK: the means to justify the ends?
K Meek, V Dang, SP Lees-Miller
Advances in immunology 99, 33-58, 2008
The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit (∗)
DW Chan, SP Lees-Miller
Journal of Biological Chemistry 271 (15), 8936-8941, 1996
Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice
X Cui, Y Yu, S Gupta, YM Cho, SP Lees-Miller, K Meek
Molecular and cellular biology 25 (24), 10842-10852, 2005
Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A
AA Goodarzi, JC Jonnalagadda, P Douglas, D Young, R Ye, ...
The EMBO journal 23 (22), 4451-4461, 2004
Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase
J Parkinson, SP Lees-Miller, RD Everett
Journal of virology 73 (1), 650-657, 1999
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