| Real time monitoring of powder blend bulk density for coupled feed-forward/feed-back control of a continuous direct compaction tablet manufacturing process R Singh, AD Román-Ospino, RJ Romañach, M Ierapetritou, ... International journal of pharmaceutics 495 (1), 612-625, 2015 | 86 | 2015 |
| Effect of tracer material properties on the residence time distribution (RTD) of continuous powder blending operations. Part I of II: Experimental evaluation MS Escotet-Espinoza, S Moghtadernejad, S Oka, Y Wang, ... Powder Technology 342, 744-763, 2019 | 84 | 2019 |
| Assessment of blend uniformity in a continuous tablet manufacturing process NO Sierra-Vega, A Román-Ospino, J Scicolone, FJ Muzzio, ... International journal of pharmaceutics 560, 322-333, 2019 | 73 | 2019 |
| Near infrared spectroscopic calibration models for real time monitoring of powder density AD Román-Ospino, R Singh, M Ierapetritou, R Ramachandran, R Méndez, ... International journal of pharmaceutics 512 (1), 61-74, 2016 | 68 | 2016 |
| Adequacy and verifiability of pharmaceutical mixtures and dose units by variographic analysis (Theory of Sampling)–A call for a regulatory paradigm shift KH Esbensen, AD Román-Ospino, A Sanchez, RJ Romañach International journal of pharmaceutics 499 (1-2), 156-174, 2016 | 58 | 2016 |
| Effect of material properties on the residence time distribution (RTD) characterization of powder blending unit operations. Part II of II: Application of models MS Escotet-Espinoza, S Moghtadernejad, S Oka, Z Wang, Y Wang, ... Powder Technology 344, 525-544, 2019 | 57 | 2019 |
| Advanced process design and understanding of continuous twin-screw granulation via implementation of in-line process analytical technologies W Meng, AD Román-Ospino, SS Panikar, C O'Callaghan, SJ Gilliam, ... Advanced Powder Technology 30 (4), 879-894, 2019 | 55 | 2019 |
| A training on: continuous manufacturing (direct compaction) of solid dose pharmaceutical products S Moghtadernejad, MS Escotet-Espinoza, S Oka, R Singh, Z Liu, ... Journal of Pharmaceutical Innovation 13, 155-187, 2018 | 44 | 2018 |
| Evaluation of analytical and sampling errors in the prediction of the active pharmaceutical ingredient concentration in blends from a continuous manufacturing process JM Vargas, AD Roman-Ospino, E Sanchez, RJ Romañach Journal of Pharmaceutical Innovation 12, 155-167, 2017 | 39 | 2017 |
| Development of near infrared spectroscopic calibration models for in-line determination of low drug concentration, bulk density, and relative specific void volume within a feed … C Ortega-Zúñiga, C Pinzón-De la Rosa, AD Román-Ospino, ... Journal of pharmaceutical and biomedical analysis 164, 211-222, 2019 | 36 | 2019 |
| Prediction of dissolution profiles by non-destructive NIR spectroscopy in bilayer tablets Y Baranwal, AD Román-Ospino, G Keyvan, JM Ha, EP Hong, FJ Muzzio, ... International Journal of Pharmaceutics 565, 419-436, 2019 | 33 | 2019 |
| Applications of quantum cascade laser spectroscopy in the analysis of pharmaceutical formulations NJ Galán-Freyle, LC Pacheco-Londoño, AD Román-Ospino, ... Applied spectroscopy 70 (9), 1511-1519, 2016 | 27 | 2016 |
| Near infrared spectroscopic transmittance measurements for pharmaceutical powder mixtures A Sánchez-Paternina, AD Román-Ospino, M Martínez, J Mercado, ... Journal of pharmaceutical and biomedical analysis 123, 120-127, 2016 | 26 | 2016 |
| Sampling optimization for blend monitoring of a low dose formulation in a tablet press feed frame using spatially resolved near-infrared spectroscopy AD Román-Ospino, Y Baranwal, J Li, J Vargas, B Igne, S Bate, ... International Journal of Pharmaceutics 602, 120594, 2021 | 22 | 2021 |
| Combined feedforward/feedback control of an integrated continuous granulation process GC Pereira, SV Muddu, AD Román-Ospino, D Clancy, B Igne, C Airiau, ... Journal of Pharmaceutical Innovation 14, 259-285, 2019 | 22 | 2019 |
| Residence time distribution modelling and in line monitoring of drug concentration in a tablet press feed frame containing dead zones S Tanimura, R Singh, AD Román-Ospino, M Ierapetritou International Journal of Pharmaceutics 592, 120048, 2021 | 20 | 2021 |
| Characterization of NIR interfaces for the feeding and in-line monitoring of a continuous granulation process AD Román-Ospino, A Tamrakar, B Igne, ET Dimaso, C Airiau, DJ Clancy, ... International Journal of Pharmaceutics 574, 118848, 2020 | 16 | 2020 |
| A procedure for developing quantitative near infrared (NIR) methods for pharmaceutical products RJ Romañach, AD Román-Ospino, M Alcalà Process Simulation and Data Modeling in Solid Oral Drug Development and …, 2016 | 16 | 2016 |
| Classical least squares-assisted mid-infrared (MIR) laser spectroscopy detection of high explosives on fabrics LC Pacheco-Londoño, JA Aparicio-Bolaño, NJ Galán-Freyle, ... Applied Spectroscopy 73 (1), 17-29, 2019 | 14 | 2019 |
| Theory of Sampling (TOS): a necessary and sufficient guarantee for reliable multivariate data analysis in pharmaceutical manufacturing KH Esbensen, RJ Romañach, AD Román-Ospino Multivariate Analysis in the Pharmaceutical Industry, 53-91, 2018 | 14 | 2018 |
Rodolfo J RomanachUniversity of Puerto Rico at Mayaguez, Department of Chemistry, C-SOPSDirección de correo verificada de upr.edu
