David Robert Westhead
David Robert Westhead
Professor of Bioinformatics, University of Leeds
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Flexible docking using Tabu search and an empirical estimate of binding affinity
CA Baxter, CW Murray, DE Clark, DR Westhead, MD Eldridge
Proteins: Structure, Function, and Bioinformatics 33 (3), 367-382, 1998
Improved prediction of protein–protein binding sites using a support vector machines approach
JR Bradford, DR Westhead
Bioinformatics 21 (8), 1487-1494, 2005
A primer on learning in Bayesian networks for computational biology
CJ Needham, JR Bradford, AJ Bulpitt, DR Westhead
PLoS computational biology 3 (8), e129, 2007
A unique dual activity amino acid hydroxylase in Toxoplasma gondii
EA Gaskell, JE Smith, JW Pinney, DR Westhead, GA McConkey
PloS one 4 (3), e4801, 2009
Gene-expression profiling of bortezomib added to standard chemoimmunotherapy for diffuse large B-cell lymphoma (REMoDL-B): an open-label, randomised, phase 3 trial
A Davies, TE Cummin, S Barrans, T Maishman, C Mamot, U Novak, ...
The Lancet Oncology 20 (5), 649-662, 2019
Ligand binding: functional site location, similarity and docking
SJ Campbell, ND Gold, RM Jackson, DR Westhead
Current opinion in structural biology 13 (3), 389-395, 2003
Dynamic gene regulatory networks drive hematopoietic specification and differentiation
DK Goode, N Obier, MS Vijayabaskar, M Lie-A-Ling, AJ Lilly, R Hannah, ...
Developmental cell 36 (5), 572-587, 2016
Molecular high-grade B-cell lymphoma: defining a poor-risk group that requires different approaches to therapy
C Sha, S Barrans, F Cucco, MA Bentley, MA Care, T Cummin, H Kennedy, ...
Journal of Clinical Oncology 37 (3), 202, 2019
Evolutionary algorithms in computer-aided molecular design
DE Clark, DR Westhead
Journal of Computer-Aided Molecular Design 10, 337-358, 1996
Depletion of RUNX1/ETO in t (8; 21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding
A Ptasinska, SA Assi, D Mannari, SR James, D Williamson, J Dunne, ...
Leukemia 26 (8), 1829-1841, 2012
RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis
M Lichtinger, R Ingram, R Hannah, D Müller, D Clarke, SA Assi, ...
The EMBO journal 31 (22), 4318-4333, 2012
A comparison of heuristic search algorithms for molecular docking
DR Westhead, DE Clark, CW Murray
Journal of Computer-Aided Molecular Design 11, 209-228, 1997
Arabidopsis Co-expression Tool (ACT): web server tools for microarray-based gene expression analysis
IW Manfield, CH Jen, JW Pinney, I Michalopoulos, JR Bradford, ...
Nucleic acids research 34 (suppl_2), W504-W509, 2006
A comparative study of machine-learning methods to predict the effects of single nucleotide polymorphisms on protein function
VG Krishnan, DR Westhead
Bioinformatics 19 (17), 2199-2209, 2003
Petri Net representations in systems biology
JW Pinney, DR Westhead, GA McConkey
Biochemical Society Transactions 31 (6), 1513-1515, 2003
PRO_LIGAND: An approach to de novo molecular design. 1. Application to the design of organic molecules
DE Clark, D Frenkel, SA Levy, J Li, CW Murray, B Robson, B Waszkowycz, ...
Journal of computer-aided molecular design 9, 13-32, 1995
Protein structural topology: Automated analysis and diagrammatic representation
DR Westhead, TWF Slidel, TPJ Flores, JM Thornton
Protein Science 8 (4), 897-904, 1999
Chromatin accessibility-based characterization of the gene regulatory network underlying Plasmodium falciparum blood-stage development
CG Toenhake, SAK Fraschka, MS Vijayabaskar, DR Westhead, ...
Cell host & microbe 23 (4), 557-569. e9, 2018
Insights into protein–protein interfaces using a Bayesian network prediction method
JR Bradford, CJ Needham, AJ Bulpitt, DR Westhead
Journal of molecular biology 362 (2), 365-386, 2006
Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication
R Johnson, RJ Gamblin, L Ooi, AW Bruce, IJ Donaldson, DR Westhead, ...
Nucleic acids research 34 (14), 3862-3877, 2006
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