Zuben Sauna
Zuben Sauna
Principal Investigator, Food and Drug Administration
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A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity
C Kimchi-Sarfaty, JM Oh, IW Kim, ZE Sauna, AM Calcagno, SV Ambudkar, ...
Science 315 (5811), 525-528, 2007
P-glycoprotein: from genomics to mechanism
SV Ambudkar, C Kimchi-Sarfaty, ZE Sauna, MM Gottesman
Oncogene 22 (47), 7468-7485, 2003
Understanding the contribution of synonymous mutations to human disease
ZE Sauna, C Kimchi-Sarfaty
Nature Reviews Genetics 12 (10), 683-691, 2011
Recent advances in (therapeutic protein) drug development
HAD Lagassé, A Alexaki, VL Simhadri, NH Katagiri, W Jankowski, ...
F1000Research 6, 2017
Exposing synonymous mutations
RC Hunt, VL Simhadri, M Iandoli, ZE Sauna, C Kimchi-Sarfaty
Trends in Genetics 30 (7), 308-321, 2014
Silent (synonymous) SNPs: should we care about them?
R Hunt, ZE Sauna, SV Ambudkar, MM Gottesman, C Kimchi-Sarfaty
Single nucleotide polymorphisms: methods and protocols, 23-39, 2009
Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer
ZE Sauna, C Kimchi-Sarfaty, SV Ambudkar, MM Gottesman
Cancer research 67 (20), 9609-9612, 2007
Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein
ZE Sauna, SV Ambudkar
Proceedings of the National Academy of Sciences 97 (6), 2515-2520, 2000
The power of the pump: mechanisms of action of P-glycoprotein (ABCB1)
SV Ambudkar, IW Kim, ZE Sauna
European Journal of Pharmaceutical Sciences 27 (5), 392-400, 2006
Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima
CJ Tsai, ZE Sauna, C Kimchi-Sarfaty, SV Ambudkar, MM Gottesman, ...
Journal of molecular biology 383 (2), 281-291, 2008
The mechanism of action of multidrug-resistance-linked P-glycoprotein
ZE Sauna, MM Smith, M Müller, KM Kerr, SV Ambudkar
Journal of bioenergetics and biomembranes 33, 481-491, 2001
Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein: the two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect …
ZE Sauna, SV Ambudkar
Journal of Biological Chemistry 276 (15), 11653-11661, 2001
Prevalence of pre-existing antibodies to CRISPR-associated nuclease Cas9 in the USA population
VL Simhadri, J McGill, S McMahon, J Wang, H Jiang, ZE Sauna
Molecular therapy Methods & clinical development 10, 105-112, 2018
Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer
JA Ludwig, G Szakács, SE Martin, BF Chu, C Cardarelli, ZE Sauna, ...
Cancer research 66 (9), 4808-4815, 2006
The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding
SV Ambudkar, IW Kim, D Xia, ZE Sauna
FEBS letters 580 (4), 1049-1055, 2006
About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work
ZE Sauna, SV Ambudkar
Molecular cancer therapeutics 6 (1), 13-23, 2007
Fc fusion as a platform technology: potential for modulating immunogenicity
D Levin, B Golding, SE Strome, ZE Sauna
Trends in biotechnology 33 (1), 27-34, 2015
Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in human P-glycoprotein: evidence for ADP release as the rate-limiting step in the catalytic …
KM Kerr, ZE Sauna, SV Ambudkar
Journal of Biological Chemistry 276 (12), 8657-8664, 2001
Large scale analysis of the mutational landscape in HT-SELEX improves aptamer discovery
J Hoinka, A Berezhnoy, P Dao, ZE Sauna, E Gilboa, TM Przytycka
Nucleic acids research 43 (12), 5699-5707, 2015
Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections
ZE Sauna, S Shukla, SV Ambudkar
Molecular BioSystems 1 (2), 127-134, 2005
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Artículos 1–20