José María Ayuso Domínguez
José María Ayuso Domínguez
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Development and characterization of a microfluidic model of the tumour microenvironment
JM Ayuso, M Virumbrales-Muñoz, A Lacueva, PM Lanuza, ...
Scientific reports 6 (1), 36086, 2016
Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model
JM Ayuso, R Truttschel, MM Gong, M Humayun, M Virumbrales-Munoz, ...
Oncoimmunology 8 (3), 1553477, 2019
Glioblastoma on a microfluidic chip: Generating pseudopalisades and enhancing aggressiveness through blood vessel obstruction events
JM Ayuso, R Monge, A Martínez-González, M Virumbrales-Muñoz, ...
Neuro-oncology 19 (4), 503-513, 2017
Microfluidic tumor-on-a-chip model to evaluate the role of tumor environmental stress on NK cell exhaustion
JM Ayuso, S Rehman, M Virumbrales-Munoz, PH McMinn, P Geiger, ...
Science Advances 7 (8), eabc2331, 2021
A role for microfluidic systems in precision medicine
JM Ayuso, M Virumbrales-Muñoz, JM Lang, DJ Beebe
Nature communications 13 (1), 3086, 2022
Tumor-on-a-chip: A microfluidic model to study cell response to environmental gradients
JM Ayuso, M Virumbrales-Munoz, PH McMinn, S Rehman, I Gomez, ...
Lab on a Chip 19 (20), 3461-3471, 2019
Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
JM Ayuso, A Gillette, K Lugo-Cintrón, S Acevedo-Acevedo, I Gomez, ...
EBioMedicine 37, 144-157, 2018
Breast fibroblasts and ECM components modulate breast cancer cell migration through the secretion of MMPs in a 3D microfluidic co-culture model
KM Lugo-Cintrón, MM Gong, JM Ayuso, LA Tomko, DJ Beebe, ...
Cancers 12 (5), 1173, 2020
Microfluidic lumen-based systems for advancing tubular organ modeling
M Virumbrales-Muñoz, JM Ayuso, MM Gong, M Humayun, MK Livingston, ...
Chemical Society Reviews 49 (17), 6402-6442, 2020
Human tumor‐lymphatic microfluidic model reveals differential conditioning of lymphatic vessels by breast cancer cells
JM Ayuso, MM Gong, MC Skala, PM Harari, DJ Beebe
Advanced healthcare materials 9 (3), 1900925, 2020
Activated human primary NK cells efficiently kill colorectal cancer cells in 3D spheroid cultures irrespectively of the level of PD-L1 expression
PM Lanuza, A Vigueras, S Olivan, AC Prats, S Costas, G Llamazares, ...
Oncoimmunology 7 (4), e1395123, 2018
High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 cross-linking and increases antitumour effect against colon cancer
D De Miguel, A Gallego-Lleyda, JM Ayuso, D Pejenaute-Ochoa, V Jarauta, ...
Cancer letters 383 (2), 250-260, 2016
Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironment
KM Lugo-Cintrón, JM Ayuso, BR White, PM Harari, SM Ponik, DJ Beebe, ...
Lab on a Chip 20 (9), 1586-1600, 2020
Tau protein provides DNA with thermodynamic and structural features which are similar to those found in histone-DNA complex
S Camero, MJ Benitez, A Barrantes, JM Ayuso, R Cuadros, J Avila, ...
Journal of Alzheimer's Disease 39 (3), 649-660, 2014
TRAIL-coated lipid-nanoparticles overcome resistance to soluble recombinant TRAIL in non-small cell lung cancer cells
D De Miguel, A Gallego-Lleyda, JM Ayuso, S Erviti-Ardanaz, R Pazo-Cid, ...
Nanotechnology 27 (18), 185101, 2016
Study of the chemotactic response of multicellular spheroids in a microfluidic device
JM Ayuso, HA Basheer, R Monge, P Sánchez-Álvarez, M Doblaré, ...
PloS one 10 (10), e0139515, 2015
Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling
M Virumbrales-Muñoz, JM Ayuso, A Lacueva, T Randelovic, ...
Scientific Reports 9 (1), 6199, 2019
Multiwell capillarity-based microfluidic device for the study of 3D tumour tissue-2D endothelium interactions and drug screening in co-culture models
M Virumbrales-Muñoz, JM Ayuso, M Olave, R Monge, D de Miguel, ...
Scientific reports 7 (1), 11998, 2017
Agarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines
M Ahmed, HA Basheer, JM Ayuso, D Ahmet, M Mazzini, R Patel, ...
Scientific reports 7 (1), 1075, 2017
Toward improved in vitro models of human cancer
JM Ayuso, KY Park, M Virumbrales-Muñoz, DJ Beebe
APL bioengineering 5 (1), 2021
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